【Xanthohumol】Main Citrus Flavonoids with Antidiabetic Effects.

【Xanthohumol】Main Citrus Flavonoids with Antidiabetic Effects.

Xanthohumol or 3′-[3,3-dimethylallyl]-2′,4′,4-trihydroxy-6′-methoxychalcone, found in citrus plants in the family Rutaceae, is a bioactive antioxidant molecule linked to a wide range of bioactivities, including anticarcinogenic, anti-inflammatory, and antioxidant properties. A study included in our survey demonstrated that xanthohumol reduced the expression of Gal3, a protein responsible for multiple complications and diabetic progression in HFD-fed type 2 diabetic C57Bl/6 mice. In addition to reducing Gal3 expression, xanthohumol has also been shown to reduce oxidative stress biomarkers associated with diabetes such as 3-nitrotyrosine and AGEs in the liver and kidneys, validating its remedial effect against this chronic metabolic disease.